Guodong Zhang | Department of Food Science

Associate Professor

Field of Study:

Colonic inflammation, colon cancer, eicosanoid signaing, environmental exposure

Office:

Room 245, Chenoweth Laboratory

Telephone:

(413) 545-1014

Email:

guodongzhang@umass.edu

Group Site:

https://blogs.umass.edu/guodongzhang/

Details

Research

Our research focuses on prevention of colonic inflammation (inflammatory bowel disease) and colon cancer. To achieve this, we address two major issues: (1) identification and characterization of novel environmental risk factors of IBD and colon cancer. We study how environmental and dietary compounds alter gut microbiome and deregulate mucosa immune system to exaggerate colonic inflammation and colon tumorigenesis; and (2) discovery of novel therapeutic targets and biomarkers of IBD and colon cancer. We use LC-MS/MS-based lipidomics and transgenic animal models to study the roles of eicosanoid signaling in colonic inflammation and colon cancer, in order to identify novel therapeutic targets and biomarkers of these diseases.

Teaching

FS 797R: Research Methods

FS 581: Food Analysis

FS 583: Food Analysis Laboratory

Awards

Awards and Honors

2020 Samuel Cate Prescott Award, Institute of Food Technologists (IFT)

2019 Young Scientist Research Award, American Oil Chemists’ Society (AOCS)

2018 Junior Researcher Travel Award, AOCS Lipid Oxidation and Quality (LOQ) Division

2017 Travel Award, American Chemical Society (ACS)/AGFD

2017 Finalist of the Eicosanoid Research Foundation (ERF) Young Scientist Award

2016 Flex Grant for Teaching/Faculty Development, UMass-Amherst

2014 Armstrong Fund of Science Award, UMass-Amherst

2014 Travel Award and Finalist of American Chemical Society (ACS) AGFD Young Scientist Award

2014 Outstanding Poster Award, the 15th International Winter Eicosanoid Meeting

2009 Vilas Travel Grant Award, UW-Madison

2005 Hollister Fellowship, UW-Madison

Honors of advised students in the laboratory

Weicang Wang, PhD student (2014-19):

2013 Alumni Fellowship, UMass-Amherst

2017 Graduate Travel Award, American Society for Pharmacology and Experimental Therapeutics (ASPET)

2017 Micha Peleg International Travel Award, UMass-Amherst

2017 Feeding Tomorrow Graduate Scholarship, Institute of Food Technologists (IFT)

2017 Graduate Student Scholarship, Northeast Section of the Institute of Food Technologists (NEIFT)

2018 Founders Award, Honor Society of Phi Kappa Phi

2018 Outstanding Poster Award, the 17th International Winter Eicosanoid Meeting

2018 Travel Award, Honor Society of Phi Kappa Phi

2019 Health and Nutrition Division Student Award, American Oil Chemists' Society (AOCS)

2019 Honored Student Award, AOCS

2019 Chinese government award for outstanding self-financed students abroad

Katherine Z. Sanidad, PhD student (2014-19):

2017 Best Student Oral Presentation Award, Northeast Chapter of the Society of Toxicology (NESOT) Annual Meeting

2018 Graduate Travel Award, NESOT

2018 Travel Award, 24th Annual Meeting of the North Atlantic Chapter of the Society of Environmental Toxicology and Chemistry (NACSETAC)

2018 Best Poster Award, 24th Annual Meeting of NACSETAC

2020 Byron Prize Award for best Ph.D. Dissertation, Molecular and Cell Biology Program, UMass-Amherst

Jianan Zhang, PhD student (2016-2021) and postdoctoral fellow (2021-present):

2019 First place of Herbert O. Hultin Oral Competition Scholarship, UMass-Amherst

2019 Excellent poster award, UMass Life Sciences Graduate Research Symposium

2021 Best Poster Award, Pioneer Valley Microbiology Symposium, UMass-Amherst

2021 Founder’s Scholarship, Honor Society of Phi Kappa Phi

Elvira Sukamtoh, BS student (2014-16) and MS student (2016-18):

2015 Travel award, IFT

2015 2nd place of Undergraduate Research Competition, IFT

2015 Rising Researcher Award, UMass-Amherst (highest award for UMass undergraduate research: https://www.umass.edu/researchnext/researcher/destined-success)

2016 Travel award, American Chemical Society (ACS)

2016 1st place of Undergraduate Student Research Award Symposium, ACS

2016 Alumni Fellowship, UMass-Amherst

Haixia Yang, Postdoctoral fellow (2016-18):

2017 Postdoctoral Poster Award, NESOT Annual Meeting

2018 Best Postdoctoral Publication Award, Society of Toxicology

Publications

Yang H., Wang W., Romano K.A., Gu M., Sanidad K., Kim D., Yang J., Schmidt B., Panigrahy D., Pei R., Martin D.A., Ozay E.I., Wang Y., Song M., Bolling B.W., Xiao H., Minter L.M., Yang G., Liu Z., Rey F.E.*, and Zhang G.* (2018) A common antimicrobial additive increases colonic inflammation and colon tumorigenesis in mice. Science Translational Medicine 10:eaan4116. Doi: 10.1126/scitranslmed.aan4116.
Wang W., Yang J., Edin M.L., Wang Y., Luo Y., Wan D., Yang H., Sanidad K.Z., Song M., Bisbee A.H., Bradbury J.A., Nan G., Zhang J., Shih B., Lee K.S.S., Minter L.M., Kim D., Xiao H., Liu J., Hammock B.D.*, Zeldin D.C.*, and Zhang G.* (2019) Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as novel therapeutic target of colon tumorigenesis. Cancer Research 79:1822-1830.
Wang Y., Yang J., Wang W., Sanidad K.Z., Cinelli M.A., Wan D., Hwang S.H., Kim D., Lee K.S.S., Xiao H., Hammock B.D.*, and Zhang G.* (2020) Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation. PNAS 117: 8431-8436.
Wang W., Yang J., Zhang J., Wang Y., Hwang S., Qi W., Wan D., Kim D., Sun J., Sanidad K.Z., Yang H., Park Y., Liu J., Liu Z., Hammock B.D.*, and Zhang G.* (2018) Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. PNAS 115:5283-5288.
Lei L., Yang J., Zhang J., and Zhang G. (2021) The lipid peroxidation product EKODE exacerbates colonic inflammation and colon tumorigenesis. Redox Biology, in press.
Zhang H., Sanidad K.Z., Zhu L., Parsonnet J., Haggerty T.D., Zhang G.*, and Cai Z.* Frequent occurrence of triclosan hydroxylation in mammals: A combined theoretical and experimental investigation. Journal of Hazardous Materials, Doi: 10.1016/j.jhazmat.2020.124803.
Yang H., Sanidad K.Z., Wang W., Xie M., Gu M., Cao X., Xiao H.*, and Zhang G.* (2019) Triclocarban exposure exaggerates colonic inflammation and colon tumorigenesis: roles of gut microbiota involved. Gut Microbes 24:1-12. Doi: 10.1080/19490976.2019.1690364.
Sanidad K., Xiao H., and Zhang G. (2019) Triclosan, a common antimicrobial ingredient, on gut microbiota and gut health. Gut Microbes 20:1-4.
Wang Y., Wang W., Sanidad K., Shih P., Zhao X., and Zhang G. (2018) Eicosanoid signaling in carcinogenesis of colorectal cancer. Cancer Metastasis Review 37:257-267.
Wang Y., Wang W., Yang H., Shao D., Zhao X., and Zhang G. (2019) Intraperitoneal injection of 4-hydroxynonenal (4-HNE), a lipid peroxidation product, exacerbates colonic inflammation through activation of Toll-like receptor 4 signaling. Free Radical Biology & Medicine 131:237-242.

Full CV

CV Guodong.pdf